PainTrace® in research can be used for:

  • Stratification - Tailored methodology can enhance the validity of your findings.
  • Pilot Trials - Strengthen your application and protocol by providing evidence of your study's design and its relevance to addressing pain-related issues. Phase
  • Studies - Smaller, well-defined groups can yield significant insights into pain measurement and improve the precision of your findings.

ACHIEVE YOUR GOALS

Book a meeting to discuss PainTrace® in research.

How do we turn PainTrace® data into meaningful insights in research?

PainTrace® is an objective neurobiosignature correlated with human self-reported pain

PainTrace differentiates acute and chronic pain, measuring both magnitude and duration of the pain experience.

Quantify the individual experience of pain with an objective outcome measure to strengthen research conclusions.

The PainTrace® Pain Scale

PainTrace-Pain Scale Explainer Chart

Interpreting the PainTrace Pain Scale

  • Baseline Value

    The PainTrace Baseline measures chronic pain - positive values indicate degree of non-painful state and increasing negative values indicate mild, moderate, and severe chronic pain state.

  • Pain Peaks

    The PainTrace Acute Peaks quantify acute pain in response to in response to applied stimuli such as examination, movement, or touch. Peak amplitudes are highlighted by intensity.​

https://paintrace.com/wp-content/uploads/2020/11/cropped-favicon.png

How do we turn PainTrace® data into meaningful insights in research?

The PainTrace® Pain Scale

PainTrace® is an objective neurobiosignature correlated with human self-reported pain

PainTrace differentiates acute and chronic pain, measuring both magnitude and duration of the pain experience.

Quantify the individual experience of pain with an objective outcome measure to strengthen research conclusions.

https://paintrace.com/wp-content/uploads/2020/11/cropped-favicon.png

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PainTrace-Pain Scale Explainer Chart

Interpreting the PainTrace Pain Scale

  • Baseline Value

    The PainTrace Baseline measures chronic pain - positive values indicate degree of non-painful state and increasing negative values indicate mild, moderate, and severe chronic pain state.

  • Pain Peaks

    The PainTrace Acute Peaks quantify acute pain in response to in response to applied stimuli such as examination, movement, or touch. Peak amplitudes are highlighted by intensity.​

  • Mild Acute Pain

  • Moderate Acute Pain

  • Severe Acute Pain

CASE EXAMPLES

PainTrace® demonstrates reduced pain in 95% of lower back patients post-treatment

LowerBackPainGraph

PainTrace® was used to objectively measure pain levels in individuals with chronic lower back pain before and after treatment.
The results showed that 95% of patients experienced less pain, as evidenced by more positive or less negative PainTrace® values post-treatment.

PainTrace® Insight

  • PainTrace® Baseline values were recorded before and after treatment
  • 19 of 20 patients showed objective improvement, reinforcing treatment effectiveness
  • Patient #11 was the only outlier with increased pain post-treatment
  • PainTrace® provides a clear, individualized visualization of pain trends over time

PainTrace® demonstrates reduced pain in 95% of lower back patients post-treatment

PainTrace® Insight

  • PainTrace® Baseline values were recorded before and after treatment
  • 19 of 20 patients showed objective improvement, reinforcing treatment effectiveness
  • Patient #11 was the only outlier with increased pain post-treatment
  • PainTrace® provides a clear, individualized visualization of pain trends over time

PainTrace® was used to objectively measure pain levels in individuals with chronic lower back pain before and after treatment.
The results showed that 95% of patients experienced less pain, as evidenced by more positive or less negative PainTrace® values post-treatment.

LowerBackPainGraph

PainTrace® provides an objective measure of pain throughout the surgical recovery process

Pre-andPost-SurgicalPainGraph

Monitor Pre- and Post-Surgical Pain

Pain levels were recorded before surgery and monitored over time post-operatively. An initial increase in pain signal was observed immediately after surgery, followed by steady improvement. These values reflect reduced pain and support PainTrace® as a tool for tracking surgical recovery and long-term treatment efficacy.

Pre-Surgical Pain Levels

  • Pre-Op: PainTrace® Baseline Average = -22 
  • Indicates presence of chronic pain prior to surgery

Post-Surgical Pain Levels – Immediate Response

  • 2 Days Post-Op: PainTrace® Baseline Average = -45
  • Reflects more pain potentially from the existing chronic pain plus surgical pain

Post-Surgical Pain Levels – Recovery Phase

  • 10 Days Post-Op: PainTrace® Baseline Average = -5
  • PainTrace® values indicating less pain, with improvement when comparing to the pre-surgical pain levels

Post-Surgical Pain Levels – Sustained Recovery

  • 18 Days Post-Op: PainTrace® Baseline Average = +9
  • 25 Days Post-Op: PainTrace® Baseline Average = +4
  • 6 Months Post-Op: PainTrace® Baseline Average = +9
  • Positive values reflect sustained recovery and long-term pain relief

PainTrace® provides an objective measure of pain throughout the surgical recovery process

Pre-andPost-SurgicalPainGraph

Monitor Pre- and Post-Surgical Pain

Pain levels were recorded before surgery and monitored over time post-operatively. An initial increase in pain signal was observed immediately after surgery, followed by steady improvement. These values reflect reduced pain and support PainTrace® as a tool for tracking surgical recovery and long-term treatment efficacy.

Pre-Surgical Pain Levels

  • Pre-Op: PainTrace® Baseline Average = -22 
  • Indicates presence of chronic pain prior to surgery

Post-Surgical Pain Levels – Immediate Response

  • 2 Days Post-Op: PainTrace® Baseline Average = -45
  • Reflects more pain potentially from the existing chronic pain plus surgical pain

Post-Surgical Pain Levels – Recovery Phase

  • 10 Days Post-Op: PainTrace® Baseline Average = -5
  • PainTrace® values indicating less pain, with improvement when comparing to the pre-surgical pain levels

Post-Surgical Pain Levels – Sustained Recovery

  • 18 Days Post-Op: PainTrace® Baseline Average = +9
  • 25 Days Post-Op: PainTrace® Baseline Average = +4
  • 6 Months Post-Op: PainTrace® Baseline Average = +9
  • Positive values reflect sustained recovery and long-term pain relief

Chronic Pain with NSAID's for 18 weeks

NSAID

Effect on PainTrace® Baseline values, indicating chronic pain state, with the administration of NSAIDs over 18 weeks

PainTrace can be used to track chronic pain and assess treatment efficacy by comparing baseline averages across the pre-treatment, active treatment, and post-treatment phases. Changes in the baseline average reflect shifts in the chronic pain state, providing objective insight into therapeutic impact.

Chronic Pain – Pre-NSAID

  • 04-Mar to 09-Mar
  • Baseline Average = -6.43

Chronic Pain – During NSAID Treatment

  • 01-Apr to 21-Jul
  • Baseline Average = +3.23 
  • Baseline Delta (Pre-Treatment to NSAID Administration Phase) = +9.66

Chronic Pain – Post-NSAID

  • 03-Nov
  • Baseline Average = -1.3 

PainTrace Insight

  • PainTrace Baseline Average indicated chronic pain (-6.43) prior to NSAID treatment
  • Improvement to a pain-free Baseline Average (+3.23) while administering NSAID
  • After stopping NSAIDs the Baseline Average returned to a chronic pain state (-1.3)

Chronic Pain with NSAID's for 18 weeks

Chronic Pain – Pre-NSAID

  • 04-Mar to 09-Mar
  • Baseline Average = -6.43

Chronic Pain – During NSAID Treatment

  • 01-Apr to 21-Jul
  • Baseline Average = +3.23 
  • Baseline Delta (Pre-Treatment to NSAID Administration Phase) = +9.66

Chronic Pain – Post-NSAID

  • 03-Nov
  • Baseline Average = -1.3 

PainTrace Insight

  • PainTrace Baseline Average indicated chronic pain (-6.43) prior to NSAID treatment
  • Improvement to a pain-free Baseline Average (+3.23) while administering NSAID
  • After stopping NSAIDs the Baseline Average returned to a chronic pain state (-1.3)
NSAID

Effect on PainTrace® Baseline values, indicating chronic pain state, with the administration of NSAIDs over 18 weeks

PainTrace can be used to track chronic pain and assess treatment efficacy by comparing baseline averages across the pre-treatment, active treatment, and post-treatment phases. Changes in the baseline average reflect shifts in the chronic pain state, providing objective insight into therapeutic impact.

“To better understand chronic pain, we first need to address the problem of how to evaluate the severity of pain.”

(Objective Pain Assessment: a Key for the Management of Chronic Pain. F1000 Research)

THE CHALLENGES

90% of Pain Studies Fail

  • "The overall probability of succesful development of all pain medications from phase 1 to approval is 10.4%" and success in the development of new therapeutics with low abuse potential is even lower at 4.7%.

(Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs from 2000 to 2020; Anesthesiology)

Costly studies to perform

  • Pain studies cost 1.6 times more than other studies
  • Pain and anesthesia trials rank in the 3rd most expensive by therapeutic area for phase 2, 3, and 4

(Examination of Clinical Trial Costs and Barriers for Drug Development; US Department of Health and Human Services)

Clinical-Trial-Costs

THE IMPACT

1. Quantitative Measure •Support animal welfare with a pain neurobiosignature for non-verbal patients •Objective acute and chronic pain measurement using proprietary electrodermal sensors 2. Stratification •Normalize populations specific to existing pain in each subgroup, reducing selection bias •Individual bio signal to uniquely represent each study participant 3. Inter-Species Translation •Multi-species neurobiosignal to facilitate translation of animal models between species •Objective measurement of subclinical and clinical pain in multiple species 4. Ethical Inclusion and Diversity •Mandated diversity and inclusion by research funding agencies •Individual biosignal to address the importance of ethical diversity and precision 5. Efficiency •80% power achieved with cohorts under 15 based on current studies •Objective individual pain measurement from stratification through outcomes

THE PROCESS

We will collaborate with you from the beginning to the end. Our team is dedicated to assisting you at every stage by offering protocol development, an objective pain outcome measure, comprehensive analytics and statistical reporting, and top-quality support. We ensure that you have all the resources and expertise needed to conduct your research.

PainTrace® Partnership Program

2019-01-01

Discovery

Share goals and learn how PainTrace can optimize your research.

2020-01-01

Protocol Review & Consultation

Work with our team and confidentiality to develop the scope of work. 

2021-01-01

Study Implementation

PainTrace study resources and comprehensive training. Study kick-off and ongoing support. 

2019-01-01

Final Report

PainTrace objective analysis based on study protocol.

THE PROCESS

We will collaborate with you from the beginning to the end. Our team is dedicated to assisting you at every stage by offering protocol development, an objective pain outcome measure, comprehensive analytics and statistical reporting, and top-quality support. We ensure that you have all the resources and expertise needed to conduct your research.

PainTrace® Partnership Program

2019-01-01

Discovery

Share goals and learn how PainTrace can optimize your research.

2019-01-01

2020-01-01

Protocol Review & Consultation

Work with our team and confidentiality to develop the scope of work. 

2020-01-01

2021-01-01

Study Implementation

PainTrace study resources and comprehensive training. Study kick-off and ongoing support. 

2021-01-01

2019-01-01

Final Report

PainTrace objective analysis based on study protocol.

2019-01-01

Use PainTrace® in Your Research Protocol!

Contact us to find out how PainTrace impacts your research goals.

  1. Naomi Elster.  How an objective measure of pain could counter bias in medicine.  https://www.bbc.com/future/article/20230414-the-search-for-an-objective-measure-of-pain. BBC The Health Gap; 16 April 2023. 
  2. Dermot P. Maher, MD, MS, MHS, Chi Heem Wong, PhD., Kien Wei Siah, PhD., and Andrew W. Lo, PhD.  Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs from 2000 to 2020; Anesthesiology 2022; 137:243-51.

  3. Aylin Sertkaya, Anna Brikenback, Ayesha Berlind, and John Eyraud. Examination of Clinical Trial Costs and Barriers for Drug Development; Report submitted to U.S. Department of Health and Human Services; 2014.

  4. Xiaohan Xu et al.  Objective Pain Assessment: a Key for the Management of Chronic Pain. F1000 Research; 2020; 9: F1000 Faculty Rev-35.

  5. Anke Samulowitz, Ida Gremyr, Erik Eriksson and Gunnel Hensing.  “Brave Men” and “Emotional Women”: A Theory-Guided Literature Review on Gender Bias in Health Care and Gendered Norms towards Patients with Chronic Pain.  Pain Research and Management: Volume 2018 Article ID 6358624.

  6. Carmen R. Green, MD, Karen O. Anderson, PhD, Tamara A. Baker, PhD, Lisa C. Campbell, PhD, Sheila Decker, PhD, Roger B. Fillingim, PhD, Donna A. Kaloukalani, MD, MPH, Kathyrn E. Lasch, PhD, Cynthia Myers, PhD, Raymond C. Tait, PhD, Knox H. Todd, MD, MPH, and April H. Vallerand, PhD, RN.  The Unequal Burden of Pain: Confronting Racial and Ethnic Disparities in Pain.  Pain Medicine; 2003: Vol 4 , No 3:277-294.